Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic mice

Biological & Pharmaceutical Bulletin 2007 Feb;30(2):234-6

Mi-Ja Kim1,2, Kyung Hee Jung,3 Yoon Kyung Uhm,3 Kang-Hyun Leem,4 and Hye Kyung Kim,5

1) Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University
2) Imagine Obesity Institute, 117 Purynsol Mun Wa Gyun, Kyung Hee University
3) Department of Pharmacology, College of Medicine, Kyung Hee University
4) College of Korean Medicine, Semyung University
5) Department of Food and Biotechnology, Hanseo University

Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic β-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved β-cell mass in db/db mice. The present data suggest that ERW may protects β-cell damage and would be useful for antidiabetic agent.

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